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Monitoring Report: GLP-1 RA Prescribing Trends - June 2024 Data | medRxiv

Participants who started at 2 mg (lower starting dose) experienced fewer GI side effects than those who started at 4 mg, even when both groups eventually reached the same maintenance dose

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The cardiovascular outcome studies under way for incretin-based medications (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results - A Long Term Evaluation [LEADER] with liraglutide [clinicaltrials.gov, NCT01179048] [27], Exenatide Study of Cardiovascular Event Lowering [EXCSEL] with exenatide once weekly [NCT01144338], Trial Evaluating Cardiovascular Outcomes with Sitagliptin [TECOS] with sitagliptin [NCT00790205], Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus [SAVOR-TIMI 53] with saxagliptin [NCT01107886] [28], and Cardiovascular Outcome Study of Linagliptin versus Glimepiride in Patients with Type 2 Diabetes (CAROLINA) with linagliptin [NCT01243424]) will help in that respect, although the number of events from a single trial will probably be too low for definite answers